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KeynotesWe are proud to announce that Maria Xose Rodriguez-Alvarez (University of Vigo) and Ruth Keogh (London School of Hygiene and Tropical Medicine) will deliver keynote sessions.
Computational Methods for Multidimensional P-Splines:
Advances and Applications in Agriculture and Neuroscience Maria Xose Rodriguez-Alvarez (University of Vigo)
Multidimensional P-splines are a powerful tool for modelling complex, non-linear interactions. However, their application is often constrained by high computational costs, especially when complex smoothing structures, such as anisotropy or local adaptiveness, are required. This talk focuses on recent advancements in computational methods for multidimensional P-splines, offering efficient solutions to these challenges. Through two case studies, we demonstrate how these methods alleviate the computational burden, facilitating the practical application of multidimensional P-splines to complex, real-world data across diverse research fields. The first case study presents a spatio-temporal P-spline hierarchical model for analysing high-throughput phenotyping (HTP) data in agricultural experiments. Using this approach, we model the temporal evolution of genetic effects on a given phenotype, while accounting for spatio-temporal noise and experimental design/post-blocking factors. In the second case study, we introduce a novel anisotropic, locally adaptive P-spline model designed to capture sharp transitions in spatial and spatio-temporal data. The model is applied to the analysis of data from experiments studying neuronal activity in the visual cortex, where, unlike traditional/non-adaptive P-splines, it effectively identifies the spatio-temporal properties of receptive fields.
Trial Emulation in Cystic Fibrosis
Ruth Keogh (London School of Hygiene and Tropical Medicine) |
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